Chinese skullcap (Scutellaria baicalensis) also known as Baikal skullcap, is a species of flowering plant in the mint family.
- Flavons (a type of flavonoid)
- Baicalein is one of Chinese skullcap’s active ingredients.
Disease / Symptom Treatment
Type 2 diabetes mellitus (T2DM)
Wogonin, an active ingredient in Chinese skullcap, was effective in inhibiting colonic motility, probably through the opening of KCa channels located in the smooth muscle apparatus. These findings suggest that wogonin may be a candidate drug for the management of dysmotility‑related diarrhea.
(Periodontopathic Bacteria) Chinese Skullcap was shown to inhibit the growth of pathogenic bacterium associated with Gingivitis, Periodontitis, Acute necrotizing ulcerative gingivitis, localized aggressive periodontitis, severe infection of the periodontium, and chronic periodontitis.
A polysaccharide isolated from Chinese Skullcap (Scutellaria baicalensis Georgi) has been shown to ameliorate colitis.
- Oral administration of the chinese skullcap polysaccharide significantly decreased the colitis disease activity index.[3:1]
- The chinese skullcap polysaccharide ameliorated colonic pathological damage.[3:2]
- The polysaccharide markedly suppressed the proinflammatory cytokines in the serum and colon.[3:3]
- The SP1-1 polysaccharide isolated from chinese skullcap has been recommended as a novel drug candidate in the treatment of colitis.[3:4]
Title: Anti‑diarrheal effect of Scutellaria baicalensis is associated with suppression of smooth muscle in the rat colon
Publication: Spandidos Publications - Experimental and Therapeutic Medicine
Date: April 2019
Study Type: Animal Study
Author(s): Hyun Ju Kim Jun‑Ho La Hee Man Kim Il‑Suk Yang Tae Sik Sung
Institution(s): Seoul National University, Republic of Korea; University of Texas Medical Branch, Galveston, TX, USA; Yonsei University Wonju College of Medicine, Republic of Korea; University of Nevada, Reno, NV, USA
IPFS: ipfs.io, cloudflare ↩︎
Title: Antimicrobial Effect of Natural Plant Extracts against Periodontopathic Bacteria
Date: January 2019
Study Type: In Vitro
Author(s): Lee, Seung-Hee;Kim, Min-Jeong
Publication: The Journal of the Korea Contents Association
IPFS: ipfs.io, cloudflare ↩︎
Title: Polysaccharide from Scutellaria baicalensis Georgi ameliorates colitis via suppressing NF-κB signaling and NLRP3 inflammasome activation
Author(s): Li Cui, Wei Wang, Yi Luo, Qing Ning, Zhi Xia, Juan Chen, Liang Feng, Hua Wang, Jie Song, Xiaobin Tan, Wei Tan, Chengcheng Wang, Xiaobin Jia
Institution(s): Affliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, PR China; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, Jiangsu, PR China
Publication: International Journal of Biological Macromolecules
Date: March 2019
Study Type: Animal Study, Human Study: In Vitro
↩︎ ↩︎ ↩︎ ↩︎ ↩︎