Chinese Skullcap


Article Outline
  1. 1. Composition
  2. 2. Healing Properties
    1. 2.1. Antimicrobial
      1. 2.1.1. Antibacterial
      2. 2.1.2. Antiviral
    2. 2.2. Anticancer
    3. 2.3. Anti‑diarrheal
    4. 2.4. Oral Health
  3. 3. Disease / Symptom Treatment
    1. 3.1. Type 2 diabetes mellitus (T2DM)
    2. 3.2. Fever
    3. 3.3. Diarrhea
    4. 3.4. Periodontal infections
    5. 3.5. Ulcerative colitis

Chinese skullcap (Scutellaria baicalensis) also known as Baikal skullcap, is a species of flowering plant in the mint family.

Composition

  • Flavons (a type of flavonoid)
    • Baicalein is one of Chinese skullcap’s active ingredients.
    • Baicalin
    • Wogonin

Healing Properties

Antimicrobial

Antibacterial

Antiviral

Anticancer

Anti‑diarrheal

Oral Health

Disease / Symptom Treatment

Type 2 diabetes mellitus (T2DM)

Fever

Diarrhea

Wogonin, an active ingredient in Chinese skullcap, was effective in inhibiting colonic motility, probably through the opening of KCa channels located in the smooth muscle apparatus. These findings suggest that wogonin may be a candidate drug for the management of dysmotility‑related diarrhea.[1]

Periodontal infections

(Periodontopathic Bacteria) Chinese Skullcap was shown to inhibit the growth of pathogenic bacterium associated with Gingivitis, Periodontitis, Acute necrotizing ulcerative gingivitis, localized aggressive periodontitis, severe infection of the periodontium, and chronic periodontitis.[2]

Ulcerative colitis

A polysaccharide isolated from Chinese Skullcap (Scutellaria baicalensis Georgi) has been shown to ameliorate colitis.[3]

  • Oral administration of the chinese skullcap polysaccharide significantly decreased the colitis disease activity index.[3:1]
  • The chinese skullcap polysaccharide ameliorated colonic pathological damage.[3:2]
  • The polysaccharide markedly suppressed the proinflammatory cytokines in the serum and colon.[3:3]
  • The SP1-1 polysaccharide isolated from chinese skullcap has been recommended as a novel drug candidate in the treatment of colitis.[3:4]

  1. Title: Anti‑diarrheal effect of Scutellaria baicalensis is associated with suppression of smooth muscle in the rat colon
    Publication: Spandidos Publications - Experimental and Therapeutic Medicine
    Date: April 2019
    Study Type: Animal Study
    Author(s): Hyun Ju Kim Jun‑Ho La Hee Man Kim Il‑Suk Yang Tae Sik Sung
    Institution(s): Seoul National University, Republic of Korea; University of Texas Medical Branch, Galveston, TX, USA; Yonsei University Wonju College of Medicine, Republic of Korea; University of Nevada, Reno, NV, USA
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  2. Title: Antimicrobial Effect of Natural Plant Extracts against Periodontopathic Bacteria
    Date: January 2019
    Study Type: In Vitro
    Author(s): Lee, Seung-Hee;Kim, Min-Jeong
    Institution(s): n/a
    Publication: The Journal of the Korea Contents Association
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  3. Title: Polysaccharide from Scutellaria baicalensis Georgi ameliorates colitis via suppressing NF-κB signaling and NLRP3 inflammasome activation
    Author(s): Li Cui, Wei Wang, Yi Luo, Qing Ning, Zhi Xia, Juan Chen, Liang Feng, Hua Wang, Jie Song, Xiaobin Tan, Wei Tan, Chengcheng Wang, Xiaobin Jia
    Institution(s): Affliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, PR China; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, Jiangsu, PR China
    Publication: International Journal of Biological Macromolecules
    Date: March 2019
    Study Type: Animal Study, Human Study: In Vitro
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