Free radical scavenging.
Glycation is associated with several neurodegenerative disorders, including Alzheimer’s disease (AD, where it potentiates the aggregation and toxicity of proteins such as β-amyloid (Aβ).
Glycation is a process that interferes with the molecular and cellular functioning of the entire body. It involves the release of highly oxidizing side-products such as hydrogen peroxide.
- Damage by glycation results in stiffening of the collagen in the blood vessel walls, leading to high blood pressure, especially in diabetes.
- Glycations also cause weakening of the collagen in the blood vessel walls, which may lead to micro- or macro-aneurisms; this may cause strokes if in the brain.
- Parts of the body most at risk to the affects of glycation are: Long-lived cells (such as nerves and different types of brain cell), long-lasting proteins (Cells such as the retina cells in the eyes; crystallins of the lens and cornea), and DNA may accumulate substantial damage over time.
- Red blood cells have a consistent lifespan of 120 days and are easily accessible for measurement of glycation.
Polyphenol & anthocyanin-enriched extracts of blackberry help protect the brain’s microglia.[1:1]
Microglia are a type of glial cell located throughout the brain and spinal cord. Microglia account for 10–15% of all cells found within the brain. Microglia act as the first and main form of active immune defense in the central nervous system.
Disease / Symptom Treatment
Title: Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects
Publication: International Journal of Moleculary Sciences
Date: Feb 2018
Study Type: Animal Study, Commentary, Human Study: In Vitro - In Vivo - In Silico, Human: Case Report, Meta Analysis, Review
Author(s): Hang Ma, Shelby L. Johnson, Weixi Liu, Nicholas A. DaSilva, Susan Meschwitz, Joel A. Dain, and Navindra P. Seeram
Institutions: Wuyi University, Wuyishan, Nanping, Fujian, China; International Healthcare Innovation Institute (Jiangmen), Jiangmen, Guangdong, China; University of Rhode Island, Kingston, Rhode Island, USA; Salve Regina University, Newport, Rhode Island, USA
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