Ginseng


Article Outline
  1. 1. Composition
  2. 2. Healing Properties
    1. 2.1. Adaptogen
      1. 2.1.1. Exercise
        1. 2.1.1.1. Muscle Health
    2. 2.2. Anti-cancer
      1. 2.2.1. Antimetastatic
    3. 2.3. Cardiovascular Health (Heart Health)
  3. 3. Disease / Symptom Treatment
    1. 3.1. Heart Disease
      1. 3.1.1. Myocardial ischemia/reperfusion
    2. 3.2. Cancer
      1. 3.2.1. Lung Cancer

Ginseng is a perennial plant that grows in the mountains of Eastern Asia.

Composition

Most of the biological activities of ginseng are derived from its main constituents, ginsenosides.[1]

Ginsenosides or panaxosides are a class of natural steroid glycosides and triterpene saponins.

  • Compounds in this family are found almost exclusively in the plant genus Panax.

Healing Properties

Adaptogen

Panax ginseng exhibits adaptogenic properties related to the promotion of homeostasis and strengthening of systems impaired by stress.[2]

Exercise

Ginseng can be used to improve physical performance.[2:1]

Ginseng may be used to minimize the stress promoted by the practice of physical exercises.[2:2]

Muscle Health

Ginseng produced a significant reduction in the levels of creatine phosphokinase (CPK) and lactic dehydrogenase (LDH) after physical stress.[2:3]

  • CPK and LDH are associated with muscle tissue breakdown.

Anti-cancer

Ginsenoside has been shown to exhibit anticancer activity in in vivo models.[3]

Antimetastatic

Cardiovascular Health (Heart Health)

Disease / Symptom Treatment

Heart Disease

Myocardial ischemia/reperfusion

Ginsenoside Rg3, a ginsenoside found in Panax ginseng, produced significant improvement in cardiac function and decreased the levels of LDH and CPK, as well as improvement in the size of the myocardial infarct.[2:4]

Cancer

Lung Cancer

Ginsenosides Rk1 and Rg5 are promising drugs for the treatmentNon-small cell lung carcinoma (NSCLC).[3:1]


  1. Title: Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases
    Publication: Journal of Ginseng Research
    Date: August 2016
    Study Type: Review
    Author(s): Ji Hye Kim, Young-Su Yi, Mi-Yeon Kim, and Jae Youl Cho
    Institutions: Cheongju University, Cheongju, Republic of Korea; Sungkyunkwan University, Suwon, Korea; Soongsil University, Seoul, Republic of Korea
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  2. Title: Effects of Panax ginseng on the Metabolic Parameters of Rats Submitted to Swimming
    Publication: Journal of Medicinal Food
    Date: October 2019
    Study Type: Animal Study: In Vitro - In Vivo, Review
    Author(s): Victor Myung Joon Bang, Ana Luisa de Carvalho Aranão, Bruna Zampieri Nogueira, Adriano Cressoni Araújo, Patricia Cincotto dos Santos Bueno, Sandra Maria Barbalho, Maricelma da Silva Soares de Souza, and Elen Landgraf Guiguer
    Institutions: University of Marılia (UNIMAR), Marılia–Brazil, Brazil; Faculty of Food Technology of Marılia, Marı´lia, Sao Paulo–Brazil
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  3. Title: Ginsenosides Rk1 and Rg5 inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition and suppress migration, invasion, anoikis resistance, and development of stem-like features in lung cancer
    Publication: Journal of Ginseng Research
    Date: January 2021
    Study Type: Human Study: In Vitro
    Author(s): Hyunhee Kim, Pilju Choi, Taejung Kim, Youngseok Kim, Bong Geun Song, Young-Tae Park, Seon-Jun Choi, Cheol Hee Yoon, Won-Chul Lim, Hyeonseok Ko, Jungyeob Ham
    Institutions: University of Ulsan College of Medicine, Seoul, Republic of Korea; Korea Institute of Science and Technology (KIST), Gangneung, Republic of Korea; Korea Food Research Institute, Wanju, Republic of Korea; Asan Institute for Life Sciences, Seoul, Republic of Korea; University of Science and Technology (UST), Seoul, Republic of Korea
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