Nicotinamide


Article Outline
  1. 1. Healing Properties
    1. 1.1. Antiaging
    2. 1.2. Neuroprotection (neuroprotective)
    3. 1.3. Heart Health
  2. 2. Disease / Symptom Treatment
    1. 2.1. Heart Disease
      1. 2.1.1. Heart Failure
    2. 2.2. Neurodegenerative diseases
      1. 2.2.1. Parkinsons

Nicotinamide (NAD) is a form of Vitamin B3. Nicotinamide riboside (NR), a pyridine-nucleoside form of vitamin B3 and precursor to NAD+ seems to be the most vitally beneficial form to supplement with.

Healing Properties

Antiaging

Helps ameliorate age-related metabolic decline and disease.[1]

  • Improves mitochondrial biogenesis and function[1:1]

Neuroprotection (neuroprotective)

Prevents age-related dopaminergic neuronal loss (damage due to dopamine related activity in the brain) and motor decline.[1:2]

Heart Health

Disease / Symptom Treatment

Heart Disease

Heart Failure

Nicotinamide riboside supplementation attenuates the development of heart failure.[2]

  • Nicotinamide riboside efficiently rescues NAD+ synthesis in the heart and stimulates glycolysis (energy production) in cardiomyocytes (heart muscles).[2:1]
  • Nicotinamide riboside can help stabilize myocardial NAD+ levels in the failing heart.[2:2]

Neurodegenerative diseases

Parkinsons


  1. Title: The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease
    Author(s): David C. Schöndorf, Dina Ivanyuk, Pascale Baden8, Alvaro Sanchez-Martinez, Silvia De Cicco, Cong Yu, Ivana Giunta, Lukas K. Schwarz, Gabriele Di Napoli, Vasiliki Panagiotakopoulou, Sigrun Nestel, Marcus Keatinge, Jan Pruszak, Oliver Bandmann, Bernd Heimrich, Thomas Gasser, Alexander J. Whitworth, Michela Deleidi
    Institution(s): German Center for Neurodegenerative Diseases (DZNE), Helmholtz Association, Tübingen 72076, Germany, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen 72076, Germany, Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK, Department of Neuroanatomy, Institute of Anatomy and Cell Biology, University of Freiburg, Freiburg 79104, Germany, Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK,
    Publication: Cell Reports
    Date: June 2018
    Link: https://doi.org/10.1016/j.celrep.2018.05.009
    Citations: ↩︎ ↩︎ ↩︎

  2. Title: Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy
    Author(s): Nicolas Diguet, Samuel A.J. Trammell, Cynthia Tannous, Robin Deloux, Jérôme Piquereau, Nathalie Mougenot, Anne Gouge, Mélanie Gressette, Boris Manoury, Jocelyne Blanc, Marie Breton, Jean-François Decaux, Gareth G. Lavery, István Baczkó, Joffrey Zoll, Anne Garnier, Zhenlin Li, Charles Brenner, Mathias Mericskay
    Institution(s): Sorbonne Universités, Université Pierre et Marie Curie Paris 6, Department of Biology of Adaptation and Ageing, CNRS UMR8256, INSERM U1164, Institute of Biology Paris-Seine, DHU FAST, France (N.D., C.T., R.D., A. Gouge, J.B., J.-F.D., Z.L.)., Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City (S.A.J.T., C.B.)., Signalling and Cardiovascular Pathophysiology, UMR-S 1180, University Paris-Sud, INSERM, Université Paris- Saclay, Châtenay-Malabry, France (C.T., R.D., J.P., M.G., B.M., M.B., A. Garnier, M.M.)., Institute of Metabolism and Systems Research, University of Birmingham, United Kingdom (G.G.L.)., Department of Pharmacology and Pharmacotherapy, University of Szeged, Hungary (I.B.).,
    Publication:
    Date: December 7 2017
    Link: https://doi.org/10.1161/CIRCULATIONAHA.116.026099
    Citations: ↩︎ ↩︎ ↩︎